Arthritis eBook; Chapter 1, What is Arthritis

WHAT IS ARTHRITIS

Chapter 1; Introduction

Arthritis is a term coined from two Greek words, athro (joint) and itis (inflammation). It is a condition whose main presenting symptoms are pain (arthralgia), stiffness and swelling in the joints. Arthritis can affect only one joint (mono articular) or many joints (poly articular) in a person.

The presence of pain and swelling in a joint is a manifestation of an underlying condition.

Prevalence of arthritis

The prevalence of arthritis may vary from country to country. It is hard to come up with definite figures but various studies have provided estimates. An estimated 40 million Americans had arthritis and the number is expected to increase to 59.4 million by the year 2020 (18% increase). This is just an example and figures vary with country.

Lear...

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The transcriptional co-activator Bob1 is associated with pathologic B cell responses in autoimmune tissue inflammation

ABSTRACT

Objective: The molecular mechanisms steering abnormal B cell responses in autoimmune diseases remain poorly understood. In this study we aimed to identify molecular switches controlling pathological B cell responses in rheumatoid arthritis (RA).

Methods: Candidate molecules were identified by gene expression profiling of RA synovitis and validated by qPCR and immunohistochemistry. B cell-specific expression was confirmed by immunofluorescence, immunoblotting and flow cytometry. The role in pathological B cell responses was assessed in collagen-induced arthritis (CIA).

Results: Transcriptional profiling of RA synovitis revealed a prominent B-cell signature with the transcriptional co-activator Bob1 and its putative target BCMA among the most upregulated genes...

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Relief for Neck Pain

If arthritic changes in your upper spine are giving you a pain in the neck, Cleveland Clinic physical therapist Jim Edwards DPT, PT has some advice. Degeneration of the cushioning disks between vertebrae in the spine is common with age. Some people have no noticeable symptoms, but for others arthritis causes pain, stiffness and muscle weakness.

Arthritis Advisor

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Getting a Good Night’s Sleep with Arthritis Pain

The most important strategy for getting good quality sleep is to develop good sleep habits. Many people know this and may believe they follow them. “When I talk to patients about their lifestyle, I find that for most people sleep habits are not as good as they think,” says Dr. Dews. She advises going over the following checklist and making sure you are actually doing them.

Arthritis Advisor

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Statins may lower mortality risk in ankylosing spondylitis and psoriatic arthritis patients

Patients with ankylosing spondylitis or psoriatic arthritis who take statins may have as much as a 33 percent lower mortality risk, according to new research findings presented this week at the…
Arthritis / Rheumatology News From Medical News Today

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Three gene sets could predict response to rheumatoid arthritis therapies

Three gene expression signatures can help rheumatologists predict which patients are more likely to respond to tumor necrosis factor inhibitors (TNFi) or B-cell depletion therapies in patients with…
Arthritis / Rheumatology News From Medical News Today

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Fibroblasts could provide new target for treatment of rheumatoid arthritis

A study led by researchers at the University of Birmingham reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for…
Arthritis / Rheumatology News From Medical News Today

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Rheumatoid arthritis drugs – direct switch has a beneficial effect

For the first time, a multicentre study headed up by MedUni Vienna has compared the action of two rheumatoid arthritis drugs from the same class.
Arthritis / Rheumatology News From Medical News Today

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Road to Remission

Of the more than 100 types of arthritis, two account for the majority of cases—osteoarthritis and rheumatoid arthritis. While both conditions produce joint pain, the causes differ. And only rheumatoid arthritis has disease-modifying treatment. While there is still no cure, many people can achieve a state of remission or at least low disease activity. Remission from a chronic disease essentially means the absence of signs and symptoms. For rheumatoid arthritis, there are specific criteria for defining the states of remission, low-disease activity, moderate disease activity and high disease activity.

Arthritis Advisor

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